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Research
Discovery through Total Synthesis of Natural Product

Our group mainly works on total synthesis of natural products with biological activity and novel structure. Every project aim to synthesis natural product efficiently and provide sample for further chemical biology research, in the same time, student will be trained as a chemist.
Members

Zhiyu Gao (高志宇)
Postdoc
2024.9-
PhD. NWAFU 2024
Liang Shi (史良)
Ph. D. candidate
2023.9-
B. S. Shannxi University of Science and Technology (SUST)
M.S. NWAFU
Zhong Wan (万众)
Ph. D. candidate
2023.9-
B. S. Nanchang University
Xuena Lu (路雪娜)
M. S. candidate
2022.9-
B. S. Hebei University
Dantong Chen (陈丹彤)
M. S. candidate
2022.9-
B. S. Henan University
Xiaolan Xie (谢霄兰)
M. S. candidate
2023.9-
B. S. Taiyuan University of Science and Technology
Jun Ma (马俊)
M. S. candidate
2023.9-
B. S. Henan University of Technology
Yuan Zhao (赵媛)
M. S. candidate
2024.9-
B. S. NWAFU
Yiqing Li (李奕晴)
M. S. candidate
2024.9-
B. S. NWAFU
Jiayi Song (宋佳宜)
M. S. candidate
2024.9-
B. S. Henan Normal University
Yi Yao (姚怡)
M. S. candidate
2024.9-
B. S. Guizhou University
Shuqi Li (李淑琪)
M. S. candidate (From Prof. Han group)
2024.9-
B. S. Tianjin University of Traditional Chinese Medicine
Publications
In NWAFU
(00) Sheng, G.; Li, H.; Ren, L.; Luo, T. L. Hao, H. D*.; Gao, J. M*. First total synthesis of Ansatrienol K.
(00) Gao, Z. Y^‡.; Yu, L^‡.; Ren, L.; Wang, H. C.; Wang, R. Z.; Gao, J.-M.; Xue, X.-S*.; Hao, H. D*. A Unified and Bio-inspired Total Syntheses of Cochlearol B and Ganocins A-C via a Cyclobutane as Overbred Intermediate.
Preprint Version: ChemRxiv 2022.
(20) Gao, Z. Y.; Lu, X. N.; Li, Y. Q.; Ren, L*.; Hao, H. D* SyntheticProgress on the Total Synthesis of Ganoderma Meroterpenoids. Chin. J. Org. Chem. 2025, accepted. (Invited review)
(19) Li, T^‡.; Jiang, S^‡.; Dai, Y. H^‡.; Wu, X^‡.; Guo, H. H.; Shi, L.; Sang, X.; Ren, L.; Wang, J.; Shi, L.; Zhou, W. M*.; Li, H*.; Hao, H. D*. Total Synthesis and Target Identification ofMarine Cyclopiane Diterpenes. Nat. Commun. 2024, 15, 10851.
(18) Wang, H. C^‡.; Gao, Z. Y^‡.; Wang, J.; Chen, D. T.; Wang, Y. H.; Hao, H. D*.; Ren, L*. Asymmetric Synthesis of Scillascillin-type Homoisoflavonoid. Org. Lett. 2024, 26, 834-838.
(17) Guo, H. H^‡.; Ren, L^‡.; Sang, X. L.; Lu, X. N.; Li, T.; Zhou, W. M.; Rauf, A.; Hao, H. D*. Total Synthesis of Peshawaraquinone Through Late-Stage [3+2] Cycloaddition or α-Ketol Rearrangement. Org. Chem. Front. 2024, 11, 1084–1089.
Preprint Version: ChemRxiv 2022.
(16) Shi, L^‡.; Gao, Z. Y^‡.; Li, Y. Q; Dai, Y. H.; Liu, Y.; Shi, L. L*.; Hao, H. D*. Synthetic Study Toward Diterpenoid Aberrarone. Beilstein. J Org. Chem. 2022, 18, 1625-1628.
(15) Song, X. Q.; Wang, R. Z.; Shi, L.; Luo, T. L.; Gao, Z. Y.; Ren, L.; Zhou, W. M*.; Hao, H. D*. Stereoselective Synthesis of Kalafungin based on CuI-Catalyzed Tandem Reactions of Arylethynes Containing an Ortho-(1-Hydroxyethyl) Substituent with Alkyl Diazoacetates. Adv. Synth. Catal. 2021, 363, 4338-4342.
(14) Gao, Z. Y^‡.; Ren, L^‡.; Wang, R. Z.; Shi, L.; Wang, Y. H.; Su, F.; Hao, H. D*. Total Synthesis of (±)-Codonopiloneolignanin A. Org. Lett. 2021, 23, 5684-5688.
(13) Sui, G. Q; Song, X. Q.; Zhang, B. Y.; Wang, Y. H.; Liu, R. Y.; Guo, H. H.; Wang, J. M.; Chen, Q. W.; Yang, X. J.; Hao, H. D*.; Zhou, W. M*. Design, Synthesis and Biological Evaluation of Novel Neuchromenin analogues as Potential Antifungal Agent. Eur. J. Med. Chem. 2019, 173, 228-239.
(12) Sui, G. Q.; Lv, Q. Y.; Song, X. Q.; Guo, H. H.; Dai, J. T.; Ren, L.; Lee, C. S.; Zhou, W. M*.; Hao, H. D*. Chemoselective Reduction of Aldehyde via a Combination of NaBH₄ and Acetylacetone. New. J. Chem. 2019, 43, 15793-15796.
Before NWAFU
(11) Hao, H. D.; Trauner, D*. Furans as Versatile Synthons: Total Syntheses of Caribenol Aand Caribenol B. J. Am.Chem. Soc. 2017, 139, 4117-4122.
Highlight by X-MOL http://www.x-mol.com/news/5768
(10) Chang, Y.; Shi, L.; Huang, J.; Shi, L.; Zhang, Z.; Hao, H. D*.; Gong, J*.; Yang, Z*. Stereoselective Total Synthesis of 5-epi-Cyanthiwigin I via an Intramolecular Pauson-Khand Reaction as the Key Step. Org. Lett. 2018, 20, 2876-2879.
(9) Hao, H. D.; Wittlin, S.; Wu, Y*. Potent Antimalarial 1,2,4-trioxanes via Perhydrolysis of Epoxides. Chem. Eur. J. 2013, 19, 7605-7619.
Highlighted in ChemistryViews "New Route to Antimalarial Artemisinin"http://www.chemistryviews.org/details/ezine/4515011/New_Route_to_Antimalarial_Artemisinin.html
(8) Hao, H. D.; Li, Y.; Han, W. B.; Wu, Y*. A hydrogen Peroxide Based Access to Qinghaosu(Artemisinin). Org. Lett. 2011, 13, 4212-4215.
Highlighted in Org. Chem. Highlights "Natural Product Synthesis by C-H Functionalization",June, 2012 http://www.organic-chemistry.org/Highlights/2012/11June.shtm
(7) Chen, H.-J.; Hao, H. D.; Wu, Y*. Conversion of Dihydroartemisinic Acid into Dihydro-epi-deoxyarteannuin B. Eur. J. Org. Chem. 2015, 4423-4427.
(6) Chen, H.-J.; Han, W.-B.; Hao, H. D.; Wu, Y*. A Facile and Scalable Synthesis ofQinghaosu (Artemisinin). Tetrahedron. 2013, 69, 1112-1114.
(5) Chen, H.-J.; Hao, H. D.; Wu, Y*. A Clear-Cut Synthesis of Arteannuin O. Chin. J. Chem. 2013, 31, 139-142.
(4) Li, Y.; Hao, H. D.; Wittlin, S.; Wu, Y*. Simple Analogues of Qinghaosu. Chem. Asian. J. 2012 , 7, 1181-1186.
(3) Zhang, Y.; Hao, H. D.; Wu, Y*. An 1,2-Elimination Approach to the Enantioselective Synthesis of 1,3-Disubstituted Linear Allenes. Synlett. 2010, 905-908.
(2) Li, Y.; Hao, H. D.; Wu, Y*. Facile Ring-Opening of Oxiranes by H2O2 Catalyzed byPhosphomolybdic Acid. Org. Lett. 2009, 11, 2691-2694.
(1) Li, Y.; Hao, H. D.; Zhang, Q.; Wu, Y*. A Broadly Applicable Mild Method for the Synthesisof gem-Diperoxides from Corresponding Ketones or 1,3-Dioxolanes. Org. Lett. 2009, 11, 1615-1618.
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Dr. Hong-Dong Hao

Dr. Hong-Dong Hao (郝宏东)
Hongdong Hao was born and raised in Datong, Shanxi. He studied pharmacy (National Base class) in Shenyang Pharmaceutical University (SPU), and received his undergraduate degree in 2006. He then pursued graduate studies in Shanghai Institute of Organic Chemistry (SIOC) under the direction of Prof. Yikang Wu. In 2011, he joined Prof. Zhen Yang group in Peking University (PKU) as postdoc, focus on total synthesis project. In late 2013, he beceme a postdoctoral fellow with Prof. Dirk Trauner at the LMU Munich. After three years in the beautiful Munich, he joined NWAFU as an Associate Professor in 2017.
Email: hongdonghao@nwafu.edu.cn
Address: 陕西省杨凌示范区西北农林科技大学北校区理科大楼E423
College of Chemistry and Pharmacy
Northwest A&F University
Yangling 712100, No.22 Xinong Road
Shaanxi, China
Pictures
Alumni

Bachlors:
2018: 高志宇 (本组读研)，王艳海 (本组读研)，吕晴云 (本校读研)，傅红阳，张胤琳 (哈工大威海分校读研)，樊鑫瑞 (上海医药公司工作)，康晓琪
2019: 王瑞智 (本组读研), 孙启然 (日本读研)
2020: 陈倩雯 (西北工业大学读研)，孙凌志 (本校读研)，陈子玉，张正轩 (上海科技大学读研)
2021: 袁诚 (兰州大学读研)，周长泰 (北京康龙化成)
2022: 苏江 (西湖大学读研)
2023：刘钰（就业），杨雯玉（就业）
2024: 赵媛（推免本组读研），李奕晴（本组读研）
Graduates:
李慧 (2017.1-2019.6，博士研究生，CSC 博士联合培养项目，加拿大)
2021年毕业生：
隋国庆 (2017.9-2021.6 博士毕业潍坊学院) 王艳海 (2018.9-2021.6 硕士毕业公务员) 宋晓青 (2018.9-2021.6 硕士毕业目前在天津大学读博) 盛刚 (2018.9-2021.6 硕士毕业目前在兰州大学读博)
2022年毕业生：
王瑞智 (2019-2022 硕士毕业北京化工大学) 罗天龙 (2019-2022 硕士毕业上海皓元医药)
2023年毕业生：
李甜 (2019-2023 博士毕业) 史良 (2020-2023 硕士毕业本组读博) 戴元昊 (2020-2023 硕士毕业，上海交通大学读博) 张荣 (2020-2023，硕士毕业)
2024年毕业生
高志宇（2018-2024 博士毕业留组工作）郭会会（2018-2024 博士毕业，甘肃医学院）桑雪莉（2021-2024 硕士毕业，中学教师）王华超（2021-2024 硕士毕业，香港大学）
Lecture Note and Seminar:
Dirk Trauner
Zhen Yang
Baran Group
Stoltz Group
Macmillan Group
Inoue Group
Ang Li Group
Bode Lecture Note
Download Patent (CN, US, European)
Useful Links
Chemistry Reference Resolver
Bordwell pKa Tables
Mayr Reactivity Database (LMU)
Science history
Encyclopedia Britannica
Words
Since baccatin III is reasonably available from renewable plant sources, it is improbable that total synthesis will ever impace the availability of baccatin III. Thus, questions pertaining to strategy, reaction development and access to certain classes of analogs rather than a solution of the taxol ''supply problem'' fuel interest in these targets.--- Samuel J Danishefsky

A major preoccupation of synthesis has been the development of new methodology or synthetic methods. Frequently, this has led to short efficient syntheses of natural products, which serve to emphasize and illustrate the value of such research. However, this is not always the case, since some methods can be contrived into awkward strategies that are less than convincing in their design and efficiency. The method must fit the problem and not the other way around. --- Philip Magnus. Acc. Chem. Res. 1984, 17, 35.

A step is defined as an operation that does not involve any intervening purification/separation, including removal of solvent, commencing with compounds that are over $50/gram.--Michael J. Krische. J. Am. Chem. Soc. 2016, 138, 5467-5478.

Here we define a reaction step as one in which a substrate is converted to a product in a single reaction flask (irrespective of the number of transformations) without intermediate workup or purification.)-- Phil. S. Baran. Nature 2016, 532, 90-93.

Faculty are expected to be researchers and teachers, mentors, fundraisers, writers, editors, reviewers, panelists and administrators.-- Shenvi ACIE 2023

substoichiometric

Classic References
1. Still, W. C.; Gennari, C. Direct Synthesis ofZ-unsaturated esters. A useful modification of the Horner-Emmons Olefination. Tetrahedron. Lett. 1983, 24 , 4405-4408.
2.
3.

Research

Discovery through Total Synthesis of Natural Product

Our group mainly works on total synthesis of natural products with biological activity and novel structure. Every project aim to synthesis natural product efficiently and provide sample for further chemical biology research, in the same time, student will be trained as a chemist.

Members

Zhiyu Gao (高志宇)Postdoc2024.9-

Liang Shi (史良)Ph. D. candidate2023.9-

Zhong Wan (万众)Ph. D. candidate2023.9-

Xuena Lu (路雪娜)M. S. candidate2022.9-

Dantong Chen (陈丹彤)M. S. candidate2022.9-

Xiaolan Xie (谢霄兰)M. S. candidate2023.9-

Jun Ma (马俊)M. S. candidate2023.9-

Yuan Zhao (赵媛)M. S. candidate2024.9-

Yiqing Li (李奕晴)M. S. candidate2024.9-

Jiayi Song (宋佳宜)M. S. candidate2024.9-

Yi Yao (姚怡)M. S. candidate2024.9-

Shuqi Li (李淑琪)M. S. candidate (From Prof. Han group)2024.9-

Publications

In NWAFU

(00) Sheng, G.; Li, H.; Ren, L.; Luo, T. L. Hao, H. D*.; Gao, J. M*. First total synthesis of Ansatrienol K.

(00) Gao, Z. Y‡.; Yu, L‡.; Ren, L.; Wang, H. C.; Wang, R. Z.; Gao, J.-M.; Xue, X.-S*.; Hao, H. D*. A Unified and Bio-inspired Total Syntheses of Cochlearol B and Ganocins A-C via a Cyclobutane as Overbred Intermediate.

Preprint Version: ChemRxiv 2022.

(20) Gao, Z. Y.; Lu, X. N.; Li, Y. Q.; Ren, L*.; Hao, H. D* SyntheticProgress on the Total Synthesis of Ganoderma Meroterpenoids. Chin. J. Org. Chem. 2025, accepted. (Invited review)

(19) Li, T‡.; Jiang, S‡.; Dai, Y. H‡.; Wu, X‡.; Guo, H. H.; Shi, L.; Sang, X.; Ren, L.; Wang, J.; Shi, L.; Zhou, W. M*.; Li, H*.; Hao, H. D*. Total Synthesis and Target Identification ofMarine Cyclopiane Diterpenes. Nat. Commun. 2024, 15, 10851.

(18) Wang, H. C‡.; Gao, Z. Y‡.; Wang, J.; Chen, D. T.; Wang, Y. H.; Hao, H. D*.; Ren, L*. Asymmetric Synthesis of Scillascillin-type Homoisoflavonoid. Org. Lett. 2024, 26, 834-838.

(17) Guo, H. H‡.; Ren, L‡.; Sang, X. L.; Lu, X. N.; Li, T.; Zhou, W. M.; Rauf, A.; Hao, H. D*. Total Synthesis of Peshawaraquinone Through Late-Stage [3+2] Cycloaddition or α-Ketol Rearrangement. Org. Chem. Front. 2024, 11, 1084–1089.

Preprint Version: ChemRxiv 2022.

(16) Shi, L‡.; Gao, Z. Y‡.; Li, Y. Q; Dai, Y. H.; Liu, Y.; Shi, L. L*.; Hao, H. D*. Synthetic Study Toward Diterpenoid Aberrarone. Beilstein. J Org. Chem. 2022, 18, 1625-1628.

(14) Gao, Z. Y‡.; Ren, L‡.; Wang, R. Z.; Shi, L.; Wang, Y. H.; Su, F.; Hao, H. D*. Total Synthesis of (±)-Codonopiloneolignanin A. Org. Lett. 2021, 23, 5684-5688.

(13) Sui, G. Q; Song, X. Q.; Zhang, B. Y.; Wang, Y. H.; Liu, R. Y.; Guo, H. H.; Wang, J. M.; Chen, Q. W.; Yang, X. J.; Hao, H. D*.; Zhou, W. M*. Design, Synthesis and Biological Evaluation of Novel Neuchromenin analogues as Potential Antifungal Agent. Eur. J. Med. Chem. 2019, 173, 228-239.

(12) Sui, G. Q.; Lv, Q. Y.; Song, X. Q.; Guo, H. H.; Dai, J. T.; Ren, L.; Lee, C. S.; Zhou, W. M*.; Hao, H. D*. Chemoselective Reduction of Aldehyde via a Combination of NaBH4 and Acetylacetone. New. J. Chem. 2019, 43, 15793-15796.

Before NWAFU

(11) Hao, H. D.; Trauner, D*. Furans as Versatile Synthons: Total Syntheses of Caribenol Aand Caribenol B. J. Am.Chem. Soc. 2017, 139, 4117-4122.

Highlight by X-MOL http://www.x-mol.com/news/5768

(10) Chang, Y.; Shi, L.; Huang, J.; Shi, L.; Zhang, Z.; Hao, H. D*.; Gong, J*.; Yang, Z*. Stereoselective Total Synthesis of 5-epi-Cyanthiwigin I via an Intramolecular Pauson-Khand Reaction as the Key Step. Org. Lett. 2018, 20, 2876-2879.

(9) Hao, H. D.; Wittlin, S.; Wu, Y*. Potent Antimalarial 1,2,4-trioxanes via Perhydrolysis of Epoxides. Chem. Eur. J. 2013, 19, 7605-7619.

Highlighted in ChemistryViews "New Route to Antimalarial Artemisinin"http://www.chemistryviews.org/details/ezine/4515011/New_Route_to_Antimalarial_Artemisinin.html

(8) Hao, H. D.; Li, Y.; Han, W. B.; Wu, Y*. A hydrogen Peroxide Based Access to Qinghaosu(Artemisinin). Org. Lett. 2011, 13, 4212-4215.

Highlighted in Org. Chem. Highlights "Natural Product Synthesis by C-H Functionalization",June, 2012 http://www.organic-chemistry.org/Highlights/2012/11June.shtm

(7) Chen, H.-J.; Hao, H. D.; Wu, Y*. Conversion of Dihydroartemisinic Acid into Dihydro-epi-deoxyarteannuin B. Eur. J. Org. Chem. 2015, 4423-4427.

(6) Chen, H.-J.; Han, W.-B.; Hao, H. D.; Wu, Y*. A Facile and Scalable Synthesis ofQinghaosu (Artemisinin). Tetrahedron. 2013, 69, 1112-1114.

(5) Chen, H.-J.; Hao, H. D.; Wu, Y*. A Clear-Cut Synthesis of Arteannuin O. Chin. J. Chem. 2013, 31, 139-142.

(4) Li, Y.; Hao, H. D.; Wittlin, S.; Wu, Y*. Simple Analogues of Qinghaosu. Chem. Asian. J. 2012 , 7, 1181-1186.

(3) Zhang, Y.; Hao, H. D.; Wu, Y*. An 1,2-Elimination Approach to the Enantioselective Synthesis of 1,3-Disubstituted Linear Allenes. Synlett. 2010, 905-908.

(2) Li, Y.; Hao, H. D.; Wu, Y*. Facile Ring-Opening of Oxiranes by H2O2 Catalyzed byPhosphomolybdic Acid. Org. Lett. 2009, 11, 2691-2694.

(1) Li, Y.; Hao, H. D.; Zhang, Q.; Wu, Y*. A Broadly Applicable Mild Method for the Synthesisof gem-Diperoxides from Corresponding Ketones or 1,3-Dioxolanes. Org. Lett. 2009, 11, 1615-1618.

Dr. Hong-Dong Hao

Dr. Hong-Dong Hao (郝宏东)

Email: hongdonghao@nwafu.edu.cn

Address: 陕西省杨凌示范区西北农林科技大学北校区理科大楼E423College of Chemistry and PharmacyNorthwest A&F UniversityYangling 712100, No.22 Xinong RoadShaanxi, China

Pictures

Alumni

Lecture Note and Seminar:

Useful Links

Words

Classic References

Zhiyu Gao (高志宇)
Postdoc
2024.9-

Liang Shi (史良)
Ph. D. candidate
2023.9-

Zhong Wan (万众)
Ph. D. candidate
2023.9-

Xuena Lu (路雪娜)
M. S. candidate
2022.9-

Dantong Chen (陈丹彤)
M. S. candidate
2022.9-

Xiaolan Xie (谢霄兰)
M. S. candidate
2023.9-

Jun Ma (马俊)
M. S. candidate
2023.9-

Yuan Zhao (赵媛)
M. S. candidate
2024.9-

Yiqing Li (李奕晴)
M. S. candidate
2024.9-

Jiayi Song (宋佳宜)
M. S. candidate
2024.9-

Yi Yao (姚怡)
M. S. candidate
2024.9-

Shuqi Li (李淑琪)
M. S. candidate (From Prof. Han group)
2024.9-

(00) Sheng, G.; Li, H.; Ren, L.; Luo, T. L. Hao, H. D.; Gao, J. M. First total synthesis of Ansatrienol K.

(00) Gao, Z. Y^‡.; Yu, L^‡.; Ren, L.; Wang, H. C.; Wang, R. Z.; Gao, J.-M.; Xue, X.-S.; Hao, H. D. A Unified and Bio-inspired Total Syntheses of Cochlearol B and Ganocins A-C via a Cyclobutane as Overbred Intermediate.

(20) Gao, Z. Y.; Lu, X. N.; Li, Y. Q.; Ren, L.; Hao, H. D SyntheticProgress on the Total Synthesis of Ganoderma Meroterpenoids. Chin. J. Org. Chem. 2025, accepted. (Invited review)

(19) Li, T^‡.; Jiang, S^‡.; Dai, Y. H^‡.; Wu, X^‡.; Guo, H. H.; Shi, L.; Sang, X.; Ren, L.; Wang, J.; Shi, L.; Zhou, W. M.; Li, H.; Hao, H. D. Total Synthesis and Target Identification ofMarine Cyclopiane Diterpenes. Nat. Commun*. 2024, 15, 10851.

(18) Wang, H. C^‡.; Gao, Z. Y^‡.; Wang, J.; Chen, D. T.; Wang, Y. H.; Hao, H. D.; Ren, L. Asymmetric Synthesis of Scillascillin-type Homoisoflavonoid. Org. Lett. 2024, 26, 834-838.

(17) Guo, H. H^‡.; Ren, L^‡.; Sang, X. L.; Lu, X. N.; Li, T.; Zhou, W. M.; Rauf, A.; Hao, H. D. Total Synthesis of Peshawaraquinone Through Late-Stage [3+2] Cycloaddition or α-Ketol Rearrangement. Org. Chem. Front*. 2024, 11, 1084–1089.

(16) Shi, L^‡.; Gao, Z. Y^‡.; Li, Y. Q; Dai, Y. H.; Liu, Y.; Shi, L. L.; Hao, H. D. Synthetic Study Toward Diterpenoid Aberrarone. Beilstein. J Org. Chem. 2022, 18, 1625-1628.

(14) Gao, Z. Y^‡.; Ren, L^‡.; Wang, R. Z.; Shi, L.; Wang, Y. H.; Su, F.; Hao, H. D. Total Synthesis of (±)-Codonopiloneolignanin A. Org. Lett*. 2021, 23, 5684-5688.

(13) Sui, G. Q; Song, X. Q.; Zhang, B. Y.; Wang, Y. H.; Liu, R. Y.; Guo, H. H.; Wang, J. M.; Chen, Q. W.; Yang, X. J.; Hao, H. D.; Zhou, W. M. Design, Synthesis and Biological Evaluation of Novel Neuchromenin analogues as Potential Antifungal Agent. Eur. J. Med. Chem. 2019, 173, 228-239.

(12) Sui, G. Q.; Lv, Q. Y.; Song, X. Q.; Guo, H. H.; Dai, J. T.; Ren, L.; Lee, C. S.; Zhou, W. M.; Hao, H. D. Chemoselective Reduction of Aldehyde via a Combination of NaBH₄ and Acetylacetone. New. J. Chem. 2019, 43, 15793-15796.

(11) Hao, H. D.; Trauner, D. Furans as Versatile Synthons: Total Syntheses of Caribenol Aand Caribenol B. J. Am.Chem. Soc. 2017, 139*, 4117-4122.

(10) Chang, Y.; Shi, L.; Huang, J.; Shi, L.; Zhang, Z.; Hao, H. D.; Gong, J.; Yang, Z. Stereoselective Total Synthesis of 5-epi-Cyanthiwigin I via an Intramolecular Pauson-Khand Reaction as the Key Step. Org. Lett*. 2018, 20, 2876-2879.

(9) Hao, H. D.; Wittlin, S.; Wu, Y. Potent Antimalarial 1,2,4-trioxanes via Perhydrolysis of Epoxides. Chem. Eur. J*. 2013, 19, 7605-7619.

(8) Hao, H. D.; Li, Y.; Han, W. B.; Wu, Y. A hydrogen Peroxide Based Access to Qinghaosu(Artemisinin). Org. Lett*. 2011, 13, 4212-4215.

(7) Chen, H.-J.; Hao, H. D.; Wu, Y. Conversion of Dihydroartemisinic Acid into Dihydro-epi-deoxyarteannuin B. Eur. J. Org. Chem*. 2015, 4423-4427.

(6) Chen, H.-J.; Han, W.-B.; Hao, H. D.; Wu, Y. A Facile and Scalable Synthesis ofQinghaosu (Artemisinin). Tetrahedron*. 2013, 69, 1112-1114.

(5) Chen, H.-J.; Hao, H. D.; Wu, Y. A Clear-Cut Synthesis of Arteannuin O. Chin. J. Chem*. 2013, 31, 139-142.

(4) Li, Y.; Hao, H. D.; Wittlin, S.; Wu, Y. Simple Analogues of Qinghaosu. Chem. Asian. J*. 2012 , 7, 1181-1186.

(3) Zhang, Y.; Hao, H. D.; Wu, Y. An 1,2-Elimination Approach to the Enantioselective Synthesis of 1,3-Disubstituted Linear Allenes. Synlett*. 2010, 905-908.

(2) Li, Y.; Hao, H. D.; Wu, Y. Facile Ring-Opening of Oxiranes by H2O2 Catalyzed byPhosphomolybdic Acid. Org. Lett*. 2009, 11, 2691-2694.

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Address: 陕西省杨凌示范区西北农林科技大学北校区理科大楼E423
College of Chemistry and Pharmacy
Northwest A&F University
Yangling 712100, No.22 Xinong Road
Shaanxi, China